The Loesgen Lab uses a variety of state-of-the-art techniques to identify and develop drug leads from the metabolic products of microbial organisms, with a special emphasis on endophytic fungi and rare actinomycetes. Our research program currently focuses on the discovery of new anticancer, antimicrobial, and antiviral compounds from microbial sources. Our multidisciplinary approach to biomedical research brings together students and researchers from diverse backgrounds, including pharmaceutical sciences, chemistry, biochemistry, molecular biology, and microbiology. Loesgen Lab. Lab Tour. About the Loesgen Lab.
Oxepine-Pyrimidinone Natural Products: The Total Synthesis of (+/-) Janoxepin
Thèses - MS Nutrition
It is renowned for its excellent education, its cutting-edge fundamental research and its efforts to put new knowledge and innovations directly into practice. The work is organic synthesis-based and for the larger part involves natural product total synthesis and the synthesis of modified variants of bioactive natural products for structure-activity relationship SAR studies, lead optimization, structural editing and the development of tool compounds. Biochemical, cell biological, and pharmacological studies are carried out in a wide range of collaborations. Target natural products generally are chosen according to their potential antitumor or antibacterial activity. In addition, we also pursue research in medicinal chemistry with a focus on membrane transporters amino acid transporters, drug efflux pumps, endocannabinoid membrane transport ; this can involve both natural product leads a well as synthetic starting points.
McAulay, Kirsten The total synthesis of furanocembrane natural products. PhD thesis, University of Glasgow. The furanocembranes are a family of marine diterpenoids isolated from octocoral invertebrates.
Investigations of targeted natural sources in search of bioactive metabolites. The past several decades have seen a rise in the numbers of fungal infections due to an increase in the population of immune-compromised individuals. Some of the most common types of invasive fungal infections are caused by Candida, Aspergillus, and Cryptococcus species. The current treatments for systemic fungal infections remain unsatisfactory because of resistance and toxicity problems.
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