Contaminated case study

Grade health, science and social studies Grade health, science and social studies. Objectives: The students will look at four recent waterborne illness outbreaks in Canada and the United States. They will use the knowledge from the two previous classes to explain the outbreaks and elaborate on questions regarding the outbreaks. For the Teacher: It is advisable for the teacher to be familiar with the four cases prior to the presentation. The handout sheets give general information and provide links for further research. Evaluation: Active listening skills and being respectful for the person speaking can be assessed in this lesson.
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Case study: contamination of heparin with oversulfated chondroitin sulfate

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Then ten years after the disaster there was a time article that mostly explained how all the people felt at the current time. Then it told us about how the government abandoned the people of the city and it had many quotes of what people said after the event occurred. Then ten years later a magazine article came out to explain to us how we are still affected by hurricane Katrina. It explains how most of the buildings were redone. On a more general note, the tunnels did not receive any maintenance whatsoever.
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Case Studies

In late and early , a cluster of adverse events in patients receiving Heparin Sodium Injection occurred in the United States and in some countries in Europe. The adverse events were reported as being "allergic type" reactions, chiefly characterized by acute hypotension, nausea, and shortness of breath. The root cause of the cluster of adverse events was determined to be a contamination of the heparin by oversulfated chondroitin sulfate. The isolation and structure determination of this contaminant was accomplished by an FDA-led consortium of academic and government laboratories and independently by Baxter Healthcare, whose vial products were first identified in the USA as being associated with the adverse events. Oversulfated chondroitin sulfate was shown to produce acute hypotension in animal models, demonstrating that it was most likely the causative agent responsible for certain of the reported adverse events in patients receiving the contaminated heparin products.
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What happens when a deviation investigation into microbiological contamination in a water system determines the wrong root cause? Then, what happens if a corrective action is implemented that results in the contamination immediately coming back worse than it was and now also showing up as well in product samples? And what does a pharma company do if this takes place at a CMO in China?
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